I've just tried 2.1.125 after 2.0.36pre13.
I have my mouse at ttyS0, nothing at ttyS1 and an internal modem at ttyS3.
Though in 2.0.* they work fine, in 2.1.125 I cannnot open both ttyS1 and
ttyS3, trying to open the second one I get Device or resource busy.
(I didn't compile plug-n-pray, nor support for >4 serial lines.)
Boot message is the same at the two kernels:
Serial driver version 4.xx with no serial options enabled
ttyS00 at 0x03f8 (irq = 4) is a 16550A
ttyS01 at 0x02f8 (irq = 3) is a 16550A
ttyS03 at 0x02e8 (irq = 3) is a 16550A
(pci sis 486 main board, amd 5x86 133MHz processor)
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